PUBLICATIONS NEWS

EVENTS

&

[MoGlimaging] – Fully Automatic Lesion Localization and Characterization: Application to Brain Tumors Using Multiparametric Quantitative MRI Data. - Published on 21 08 2018
2018 Jul;37(7):1678-1689. doi: 10.1109/TMI.2018.2794918.

Arnaud A, Forbes F, Coquery N, Collomb N, Lemasson B, Barbier EL.

Abstract

When analyzing brain tumors, two tasks are intrinsically linked, spatial localization, and physiological characterization of the lesioned tissues. Automated data-driven solutions exist, based on image segmentation techniques or physiological parameters analysis, but for each task separately, the other being performedmanually or with user tuning operations. In this paper, the availability of quantitative magnetic resonance (MR) parameters is combined with advancedmultivariate statistical tools to design a fully automated method that jointly performs both localization and characterization. Non trivial interactions between relevant physiologicalparameters are capturedthanks to recent generalized Student distributions that provide a larger variety of distributional shapes compared to the more standard Gaussian distributions. Probabilisticmixtures of the former distributions are then consideredto account for the different tissue types and potential heterogeneity of lesions. Discriminative multivariate features are extracted from this mixture modeling and turned into individual lesion signatures. The signatures are subsequently pooled together to build a statistical fingerprintmodel of the different lesion types that captures lesion characteristics while accounting for inter-subject variability. The potential of this generic procedure is demonstrated on a data set of 53 rats, with 36 rats bearing 4 different brain tumors, for which 5 quantitative MR parameters were acquired.

Read More

Leave a Reply

Your email address will not be published. Required fields are marked *

icon 1

HTE News and Events

icon 2

Last HTE Program
Partners Publications

icon 3

Last International
Publications

This French program is organized by ITMO Cancer, in collaboration with ITMO BCDE (Cell Biology, Development and Evolution) and ITMO Technologies for Health of the National Alliance for Life Sciences and Health (AVIESAN) with the National Cancer Institute (INCA) and Inserm within the framework of the Cancer Plan. Operational management is entrusted to Inserm.
It was launch in order to develop a critical mass of resources and skills in order to conduct interdisciplinary research projects in the field of functional heterogeneity of cellular tumor relations in their ecosystem: the "HTE Program".

Initiation of HTE Program