Principal investigators: ELIZABETH COHEN-JONATHAN MOYAL & CHRISTINE TOULAS
Modeling of Glioblastoma treatment-induced resistance & heterogeneity by multi-modal imaging
8 teams working on Glioblastoma (GBM), the most aggressive brain tumor, collaborate to model GBM heterogeneity and treatment resistance. They follow three research lines with the final objective to predict patient response to treatments.
The network studies the involvement of cellular plasticity, cell/cell interactions, migratory capacities, microenvironment in GBM heterogeneity response to treatment focusing particularly on in vitro tunneling-nanotubes formations on patients stem cells and differentiated cells.
The second line is the study of GBM heterogeneity in vivo not only on animal models by magnetic resonance histology (MRH) but also with multimodal imaging data of patients.
A modeling of tumor heterogeneity and treatment – resistance defined by multi-modal imaging in GBM patients (clinical trial STEMRI) and animal models from two first research lines is performed in order to develop mathematical models for predicting the response to treatment.
This model of prediction of response to treatment will then allow the network to design, after validation in preclinical in vivo assays, clinical trials associating specific inhibitor of the pathways controlling the specific type of recurrence with radio-chemotherapy in GBM patients routinely followed by multimodal magnetic resonance imagery
This French program is organized by ITMO Cancer, in collaboration with ITMO BCDE (Cell Biology, Development and Evolution) and ITMO Technologies for Health of the National Alliance for Life Sciences and Health (AVIESAN) with the National Cancer Institute (INCA) and Inserm within the framework of the Cancer Plan. Operational management is entrusted to Inserm.
It was launch in order to develop a critical mass of resources and skills in order to conduct interdisciplinary research projects in the field of functional heterogeneity of cellular tumor relations in their ecosystem: the "HTE Program".