ONCOBIOMICS
Principal investigator: MATHIAS CHAMAILLARD
Integrating the intra-tumoral microbiome to promote understanding on tumor plasticity
The partners of Oncobiomics proposed to study the tumoral microbiome have a source of cancer heterogeneity in colon cancer. Their aim is to integrate the intra-tumoral microbiome heterogeneity in order to promote understanding on tumor plasticity and offers new therapeutic options.
Works that led up to the project
Some past studies from the network led up to this project. First, they found a high load of bacteria in colon cancer tumors when compared to non tumoral mucosa and healthy patient mucosa. Moreover, this load is linked to tumor stage. With vivo mice xenograft models, they identified that pks + bacteria induce have a tumor-promoting activity, inducing bigger tumors than other bacterial stems.
Applying digital microbiology to tumor plasticity
First, the network performs a strong characterization of a cohort of 100 colorectal resections and their 100 no tumor adjacent tissue. Samples include tumors from Grade I to grade IV. Characterization is performed at different levels:
- Bacterial level by sequencing of 16s and by topographic analysis of bacterial infiltrate
- Genomical level by exome sequencing
- Transcriptomical
- Inflammation level by Immunoscore-like analysis
Mathematic modeling
With the data gathered, the network will mathematically model the functional dependencies of microbiome and tumoral cell in order to propose new drug development ideas. New therapeutics targets will be validated with in vivo, in vitro and ex vivo models.
Oncobiomics highlights a new alternative to the usual thinking about cancer heterogeneity. Such characterization of colon cancer microbiome heterogeneity and its integration with clinical and genomic aspect of the tumor will promote a new understanding we tumor plasticity and new ways of therapeutic solutions.
- Lab name: Center of Bioinformatics, Biostatistics and Integrative Biology
- Website: https://research.pasteur.fr/en/team/evolutionary-bioinformatics/
- Affiliations: Institut Pasteur
- Address: 25-28 Rue du Dr Roux, 75015 Paris
- Contact: olivier.gascuel@pasteur.fr
- Lab name: Intestinal epithelial cell proliferation in physiology and cancer
- Website: https://www.institutcochin.fr/departments/drc/team-perret/group-b.-romagnolo
- Affiliations: Institut Cochin, Inserm U1016
- Address: 22 Rue Mechain, 75014 Paris
- Contact: beatrice.romagnolo@inserm.fr
LAST PUBLICATIONS:
- [Contribution of autophagy to intestinal homeostasis and pathology].
- [Antitumoral functions of autophagy inhibition in colorectal cancer: the intestinal microbiota and the immune system come to the rescue…].
- Autophagy, microbiota and intestinal oncogenesis.
- Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth.
- Lab name: Biomics
- Website: https://research.pasteur.fr/en/member/sean-kennedy/
- Affiliations: Institut Pasteur
- Address: 25-28 Rue du Dr Roux, 75015 Paris
- Contact: sean.kennedy@pasteur.fr
- Lab name: Center of Bioinformatics, Biostatistics and Integrative Biology
- Website: https://research.pasteur.fr/en/team/evolutionary-bioinformatics/
- Affiliations: Institut Pasteur
- Address: 25-28 Rue du Dr Roux, 75015 Paris
- Contact: christophe.malabat@pasteur.fr
- Lab name: Nods-like receptors in infection and immunity
- Website: http://www.ciil.fr/research-teams/nods-like-receptors-in-infection-and-immunity/
- Affiliations: Institut Pasteur, Inserm U1019, CNRS UMR8204, Université́ de Lille
- Address: 1 Rue du Professeur Calmette, 59000 Lille
- Contact: mathias.chamaillard@inserm.fr
- Lab name: Microbes Intestin Inflammation et susceptibilité́ de l’hôte
- Website: http://www.u-clermont1.fr/m2ish-old.html
- Affiliations: Inserm UMR 1071, Université d’Auvergne
- Address: 28, place Henri-Dunant 63001 Clermont-Ferrand
- Contact: rbonnet@chu-clermontferrand.fr
- Lab name: Stroma, Inflammation and Tissue Repair
- Website: https://research.pasteur.fr/en/team/group-lucie-peduto/
- Affiliations: Institut Pasteur, Inserm U1124
- Address: 25-28 Rue du Dr Roux, 75015 Paris
- Contact: pedutol@pasteur.fr
- Lab name: Pathogénie Microbienne Moléculaire
- Website: https://research.pasteur.fr/en/team/molecular-microbial-pathogenesis/
- Affiliations: Institut Pasteur, Inserm U1202
- Address: 25-28 Rue du Dr Roux, 75015 Paris
- Contact: philippe.sansonetti@pasteur.fr
- Lab name: Mucins, epithelial differentiation and carcinogenesis
- Website: http://crjpa.frneurosciences/mucines-differenciation-et-cancerogenese-epitheliales?lang=en
- Affiliations: Inserm UMR-S1172, JPARC
- Address: Bâtiment Biserte 1, place de Verdun 59045 Lille Cédex
- Contact: isabelle.vanseuningen@inserm.fr
This French program is organized by ITMO Cancer, in collaboration with ITMO BCDE (Cell Biology, Development and Evolution) and ITMO Technologies for Health of the National Alliance for Life Sciences and Health (AVIESAN) with the National Cancer Institute (INCA) and Inserm within the framework of the Cancer Plan. Operational management is entrusted to Inserm.
It was launch in order to develop a critical mass of resources and skills in order to conduct interdisciplinary research projects in the field of functional heterogeneity of cellular tumor relations in their ecosystem: the "HTE Program".
Initiation of HTE Program
