What is HTE?

Heterogeneity of tumors & ecosystem

In recent years, tumor heterogeneity and microenvironment/ecosystem notions were highlighted. It was observed that different subclones of the tumor cells develop and compete during the development of the tumor. This heterogeneity is a major problem for therapeutic decision when the treatment fails and new therapeutic strategies must take it into.

The genotype-phenotype map associated to epigenetic and functional alterations of proteins must be defined dynamically to characterize the resulting functional changes at the cell or clone level and to anticipate whether or not to target the clones in question.

The tumor ecosystem plays a significant role in contributing to the capabilities of a given tumor cell clone via bi-directional interactions between tumor-associated cells and tumor cells. Determining these interactions requires important investigations to define which factors should be targeted.

HTE Program microscope

Initiation of HTE Program

aviesan logo
institut national du cancer logo

This French program is organized by ITMO Cancer, in collaboration with ITMO BCDE (Cell Biology, Development and Evolution) and ITMO Technologies for Health of the National Alliance for Life Sciences and Health (AVIESAN) with the National Cancer Institute (INCA) and Inserm within the framework of the Cancer Plan. Operational management is entrusted to Inserm.

The tumor ecosystem plays a significant role in contributing to the capabilities of a given tumor cell clone via bi-directional interactions between tumor-associated cells and tumor cells. Determining these interactions requires important investigations to define which factors should be targeted.

Structure of HTE Program

HTE Structure

A steering committee composed of experts provide guidance on key issues and objectives of the HTE Program and organize regular meetings with the work packages leaders and principal investigators of the 6 networks.

The steering committee is composed of Christine Chomienne (ITMO Cancer), Alain Eychène (ITMO Cancer), Muriel Altabef (ITMO Cancer), Sylvie Robine (ITMO BCDE), Franck Lethimonnier (ITMO TS), Jean Clairambault (LJLL, INRIA), Irène Buvat (Université Paris-Sud), Daniel Louvard (Institut Curie) and Yann Gauduel (Laboratoire d’Optique Appliquée, Ecole Polytechnique- ENSTA).

 

This French program is organized by ITMO Cancer, in collaboration with ITMO BCDE (Cell Biology, Development and Evolution) and ITMO Technologies for Health of the National Alliance for Life Sciences and Health (AVIESAN) with the National Cancer Institute (INCA) and Inserm within the framework of the Cancer Plan. Operational management is entrusted to Inserm.
It was launch in order to develop a critical mass of resources and skills in order to conduct interdisciplinary research projects in the field of functional heterogeneity of cellular tumor relations in their ecosystem: the "HTE Program".

Initiation of HTE Program